Expression of the PD-1/PD-L1/PD-L2 axis is associated with moderately and poorly differentiated endometrial cancer and type II endometrial cancer, in which higher expression of PD-1, PD-L1 and PD-L2 may cause immunosuppression, which favors tumor growth and negatively affects patient survival [47]. The gene discussed is PDCD1LG2; the disease is neoplasm.