Of note, the differential expression of SNAP-25-related miRNAs as well as polymorphisms in the SNAP-25 gene (i.e. rs363050), which may result in the modulation of SNAP-25 expression, were suggested to play a pathogenic role in different brain diseases including Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis [15, 16], but also Attention Deficit Hyperactivity Disorder (ADHD) [17–21] and early-onset bipolar disorders [22]. This evidence concerns the gene SNAP25 and early-onset autosomal dominant Alzheimer disease.