Among the proteins largely explained by zBMI were leptin and insulin, hormones related to food intake and fat storage [61] and the pro-inflammatory cytokines IL-6 and IL-1 beta, both known to be elevated in subjects with obesity or with serum lipid concentrations abnormalities, leading to a state of chronic inflammation [62]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.