On top of the exposure-related risk (covering known factors leading to exposure increase such as Asian race, low body weight or high age), females were estimated on average to have a 3.7-fold higher risk of experiencing ALT or AST elevations ≥ 3 × ULN than males, and data in SSc-ILD and chronic fibrosing ILDs with a progressive phenotype other than IPF were again in line with findings from initial analyses in IPF. This evidence concerns the gene GPT and interstitial lung disease.