Moreover, forced expression of lncRNA actin filament-associated protein 1-antisense RNA1 (AFAP1-AS1), the antisense product of AFAP1, considerably deteriorated BC prognosis [13, 14] through mobilizing Wnt/β-catenin signaling [15], controlling miR-145/MTH1 axis [16], or promoting AUF1-mediated ERBB2 translation [17]. This evidence concerns the gene ERBB2 and breast cancer.