Our study observed JKAP was negatively correlated with Th1 and Th17 cells, while was not related to Th2 cells in PD patients; furthermore, we performed in vitro experiments based on CD4+ T cells isolated from PD patients, and discovered that JKAP inactivated CD4+ T cells as well as inhibited their differentiation into Th1 and Th17 cells, which further validated the clinical findings. This evidence concerns the gene CD4 and Parkinson disease.