As G6PD was previously shown to be upregulated in HIV‐1‐infected primary CD4+ T cells, during the late stages of the infection (Shytaj et al, 2020), we decided to further test the role of proviral transcription on the expression of G6PD in a longer time course of infection with a wild type and a previously described Tat‐deficient HIV‐1 (Bejarano et al, 2019). The gene discussed is G6PD; the disease is infection.