Linear mixed model analyses revealed that plasma cytokine levels of IL‐6 (p = 0.03), IL‐10 (p = 0.01), IL‐13 (p = 0.02) and IL‐17E (IL‐25) (p = 0.02) showed significantly higher levels in the OM‐85 group compared with placebo over time, which was not present in the placebo group (0 vs. 6 and 12 months, Table 3). The gene discussed is IL13; the disease is ocular melanoma.