As mentioned above, hyperglycemia activates local RAS by upregulating intracellular RAS components including renin, ACE, and chymase (an Ang II-generating enzyme) in mesangial cells, AT1R, AT2R, and renin in endothelial cells, and renin and AT1R in podocytes [62]. The gene discussed is AGTR1; the disease is Hyperglycemia.