In contrast to the fibrogenic, proinflammatory, and proliferative actions of the ACE/ Ang II/AT1 pathway, it has been demonstrated that the ACE2/Ang (1-7)/Mas axis has anti-inflammatory, anti-fibrogenic, and anti-proliferative properties and protects against glomerulosclerosis and Ang II-induced tubulointerstitial fibrosis [81, 82]. The gene discussed is AGT; the disease is glomerulosclerosis.