In addition, procoagulant phospholipids (PPL), i.e. anionic phospholipids, mainly phosphatidylserine, and a high level of coagulation factor VIII (FVIII), which is an acute-phase protein, have been associated with an increased risk of thrombosis [17, 18] also including cancer patients [7, 19–22]. This evidence concerns the gene F8 and deep vein thrombosis.