SERPINF1 and pulmonary arterial hypertension: In pulmonary fibrosis, PEDF is an angiostatic factor.[56] Furthermore, PEDF expression contributes to modulation of the inflammatory and angiogenic phenotype of the lung endothelium, which is key to several conditions such as pulmonary hypertension.[57] This non-inhibitory protein plays critical roles in many physiological and pathological processes by acting through multiple high affinity ligands and cell receptors.[55,58] PEDF is notably involved in organogenesis and the homeostatic maintenance of adult tissues/organs.