We identified relatively high Syrian Jewish carrier frequencies (>0.68%) for well‐established Ashkenazi Jewish variants with carrier frequencies over 2% in Ashkenazi Jews (nonsyndromic deafness‐associated GJB2:c.167del; congenital stationary night blindness‐associated TRPM1:36.8KB DEL; Smith‐Lemli‐Opitz‐associated DHCR7:c.964‐1G>C; and cystic fibrosis‐associated CFTR:c.3846G>A; Table 1). The gene discussed is GJB2; the disease is cystic fibrosis.