We have shown previously that at 12–16 weeks of age, HAF rats (prior to pregnancy) have increased body weight and peri‐renal fat mass along with elevated plasma insulin, glucose, and cholesterol compared with control females (Yanes et al., 2011), similar to PCOS women (Christakou & Diamanti‐Kandarakis, 2008; Diamanti‐Kandarakis, 2008; Escobar‐Morreale & San Millán, 2007). This evidence concerns the gene INS and polycystic ovary syndrome.