The multivariate model was adjusted for age, sex, years of HIV infection, years of antiretroviral therapy, number of implants, implant diameter, CD4+ levels at baseline (BL), CD8+ levels at BL, CD4+/CD8+ ratio at BL, platelet count at BL, hemoglobin level at BL, and diagnosis of mucositis. The gene discussed is CD4; the disease is HIV infectious disease.