Indeed, as soon as a pathogen is detected by the immune system, pro‐inflammatory cytokines will be released (Faix, 2013), and, an early release of TNF‐α by macrophages (through TLR4 pathway) may induce disseminated intravascular coagulation, hypotension and multiple organ failure (Lv et al., 2014). The gene discussed is TLR4; the disease is Multiple Organ Failure.