PDE5A and spinal cord injury: For example, PDE5 inhibitors improved IPSS scores for LUTS (Donatucci et al., 2011; McVary et al., 2007; Mulhall et al., 2006; Roehrborn et al., 2008; Sairam et al., 2002) and abnormal bladder symptoms in patients with spinal cord injury (Gacci et al., 2007; Taie et al., 2010).