IKZF1 alterations (including both point mutations and deleterious deletions) is the most common mutation seen in Ph‐like ALL, with other cases showing mutations and/or copy number alterations (CNA) in ETV6, EBF1, PAX5, TCF3, ERG, RAG1/2, BLNK, BCL11A, IKZF2, LEF1, MEF2C, SOX4, and SPI14 that are detectable by next‐generation sequencing (NGS). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.