Here we demonstrated that necroptosis was stimulated in CaCl2‐Ach‐induced AF mice (Figure 2), whereas inhibition of necroptosis via Nec‐1 attenuated CaCl2‐Ach‐induced AF burden and atrial structural remodeling (Figure 1), implicating the critical role of necroptosis in AF pathogenesis. The gene discussed is PCSK1; the disease is atrial fibrillation.