PCSK1 and fibrosis: However, inhibiting necroptosis with Nec‐1 (Figure 4) decreased HFD‐induced AF susceptibility and mitigated atrial fibrosis (Figure 3C–I), indicating a key role of necroptosis in AF pathogenesis in HFD‐induced AF mice, consistent with the results in CaCl2‐Ach‐induced AF model.