Meanwhile, overexpression of c‐Myc failed to wholly rescue the phenotype (Fig. S12F,G), whereas the increased formation of tumor sphere, the abilities of CRC cell migration and invasion, the expression of stemness‐related markers, and Wnt/β‐catenin signaling induced by FUBP1 overexpression were dramatically eliminated by knockdown of DVL1(Fig. 6E,F; Fig. S10B,C). Here, DVL1 is linked to neoplasm.