We found that CELF2 expression was significantly down‐regulated in bladder urothelial carcinoma (BLCA), BRCA, colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), LUAD, LUSC, prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA) and uterine corpus endometrial carcinoma (UCEC) relative to their respective adjacent normal tissues. This evidence concerns the gene CELF2 and prostate adenocarcinoma.