We found that the AUC of serum eotaxin and/or IP‐10 combined with CEA and CYFRA21‐1 was higher than that of CEA and/or CYFRA21‐1 alone, including for patients with both advanced and early‐stage (0‐IIA) ESCC. The gene discussed is CCL11; the disease is esophageal squamous cell carcinoma.