In accordance with the ROC curve derived from the ESCC group versus the control group, the optimal cutoff value of eotaxin was 68.23 pg/ml (sensitivity 34.50%, specificity 82.44%) and that of IP‐10 was 37.70 pg/ml (sensitivity 30.05%, specificity 84.90%). The gene discussed is CXCL10; the disease is esophageal squamous cell carcinoma.