Gene expression variability in BRCA2-associated tumours was inconsistent, with the Waddell dataset showing comparable variability with BRCAx tumours (Supplementary Fig. 2), but the Larsen dataset showing only a modest 11.1% (95% CI 10.6–11.6) increase in variability in BRCA2-associated tumours compared to BRCAx tumours. This evidence concerns the gene BRCA2 and neoplasm.