FOLH1 and neoplasm: However, if this theory is true, then one would suspect that the amount of SG blocking actually achieved in patients will likely be highly unreliable and unreproducible, as the amount of cold PSMA ligand that the SG is exposed to will be heavily influenced by factors such as differences in each individual patient’s tumor load, amount of physiologic uptake in organs such as the liver/kidneys, and other pharmacokinetic variables.