CLIC3 and cancer: After internalization, the integrin heterodimers are recycled back to the plasma membrane via a short, Rab4-dependent pathway or a long, Rab11-dependent pathway (Roberts et al., 2001); and in cancer cells, Rab25 sorts ligand-free integrins for recycling at the leading edge and ligand-bound integrins to lysosomes, where they reach the plasma membrane and cell rear in a CLIC3-dependent manner (Dozynkiewicz et al., 2012).