CAV1 and central nervous system cancer: As shown in Table 1 and Figure 1A and B, Cav-1 expression was significantly upregulated in high-grade gliomas (HGG) compared with low-grade gliomas (LGG), as evidenced by dramatically increased H-scores of CAV-1 in HGG compared with those in LGG (24.85±2.922 vs 8.318±1.016, P<0.0001).