Interestingly, patients with Cav-1 overexpression and increased VM formation in combination had shorter survival time than those with Cav-1 overexpression or increased VM formation alone or with Cav-1 downregulation and inhibited VM formation in combination, suggesting a synergistic effect between Cav-1 expression and VM formation on glioma development and progression. The gene discussed is CAV1; the disease is glioma.