Both mRNA and protein levels of Akt and HIF-1α were elevated by Cav-1 overexpression but suppressed by siCav-1 in U251 cells (Figure 4A and B), and p-Akt level was significantly increased by Cav-1 overexpression (Figure 4C), suggesting that activated Akt signal pathway may be involved in Cav-1-induced glioma cell proliferation and VM formation. This evidence concerns the gene CAV1 and central nervous system cancer.