To determine whether Cav-1 functions in glioma development and progression, tumor cell proliferation, HUVEC tubule formation, and VM formation were examined using vectors expressing Cav-1 or siCav-1 (see Supplementary Figure S1) to overexpress or knock-down Cav-1 in U251 glioma cells, respectively. The gene discussed is CAV1; the disease is neoplasm.