In order to study the effect of resveratrol on the PI3K–AKT, MAPK, and NFκB pathways, involved in myopia progression, ARPE-19 cells were incubated with TNF-α, IL-6, and IL-1β, alone and with combinations of these cytokines, for 10 min prior to the 10 min treatment with resveratrol. This evidence concerns the gene IL6 and myopia.