MMP2 and myopia: In myopic eyes, various molecules have been shown to be involved in myopia development, including transforming growth factor (TGF)-β, matrix metalloproteinase (MMP)-2, and collagen I. TGF-β is expressed in ocular tissues and is known to remodel the scleral extracellular matrix (ECM) [4,5,6], resulting in reduced collagen production.