In respiratory disease, considering asthma as an example of a disease that mainly presented with lower respiratory tract chronic inflammation, increased airway hyperresponsiveness (AHR), and mucus production, resveratrol treatment induced reductions in IL-4, IL-5, TNF-α, and TGF-β cytokine levels in an OVA-induced asthma model [34]. This evidence concerns the gene IL4 and asthma.