In respiratory disease, considering asthma as an example of a disease that mainly presented with lower respiratory tract chronic inflammation, increased airway hyperresponsiveness (AHR), and mucus production, resveratrol treatment induced reductions in IL-4, IL-5, TNF-α, and TGF-β cytokine levels in an OVA-induced asthma model [34]. The gene discussed is TNF; the disease is airway hyperresponsiveness.