Our results showed that high WNT8B expression was an independent prognostic factor for poor NPC patient survival, with a relative risk of death of 1.744 (95% confidence interval: 1.005–3.025, p-value = 0.048), among another established prognostic risk factor, systemic metastasis (p < 0.001). The gene discussed is WNT8B; the disease is nasopharyngeal carcinoma.