This is the first study of the relationship between COMT rs4818 or MAO-B rs6651806 polymorphisms and anhedonia, the first inclusion of ethnically homogenous Caucasian patients with schizophrenia, and the first detailed analysis of results, controlled for possible confounders (age of the patients, sex, smoking, alcohol consumption, history of drug abuse, history of suicide attempts and therapeutic dose of antipsychotic in chlorpromazine equivalents), in the evaluation of symptoms with the CAINS, BNSS, RPAS and RSAS, in patients with schizophrenia. Here, COMT is linked to schizophrenia.