ORFV OV20.0 protein, an ortholog of the vaccinia virus (VACV) E3, with a similar innate immune evasion mechanism, can interact with PKR and its two known activators, double-stranded DNA (dsRNA) and the cellular PKR activator (PACT), thus establishing efficient viral infection by inhibiting PKR activation (5). Here, EIF2AK2 is linked to viral infectious disease.