MRC1 and Granuloma: While our model specifically stained for CD206+ AM, it is well understood that the stages in granuloma progression are characterized by an ever-changing macrophage milieu; as such, our model can be considered a reflection of the early stages of granuloma progression, and future experiments using this model should investigate the progression of the granuloma further, specifically investigating the proportions of tissue-resident macrophages (CD68+) and other subsets like monocyte-derived macrophages to the here-reported alveolar macrophage subset (1, 43).