To investigate the clinical significance and usefulness of roxi/total, red/roxi and [red + oxi]/roxi as the redox-IDX-apoE, we selected 16 subjects with atherosclerosis combined with type 2 diabetes (56.8 ± 19.6 years) and 38 subjects with normolipidemia and no apparent disease (controls, 54.7 ± 17.0 years) from the above-mentioned 218 subjects with apoE3/E3. This evidence concerns the gene APOE and type 2 diabetes mellitus.