These findings confirm previous association of IL-8 with mesenchymal glioma stem-like cells (GSCs).28 IL-8 has also been suggested to recruit neutrophils in glioma supporting our finding of CXCL8 association with neutrophils.29 The dual association we found of CXCL8 with NK cells is less clear. Here, CXCL8 is linked to central nervous system cancer.