In GBM, IL-8 has been associated with proliferation, invasion, angiogenesis, and vascular mimicry.24,25 Few studies have previously evaluated the prognostic impact of plasma IL-8 and did not find prognostic significance,26,27 but these results are based on smaller cohorts (14–23 patients) of GBM patients, which may be too few patients to reveal a potential association with survival. Here, CXCL8 is linked to glioblastoma.