In this model, the age of 6 months can beconsidered cognitively pre-symptomatic since the rats do not show cognitive impairment (withthe exception of one study that did report a cognitive impairment at this age) while theypresent some amyloid pathology, low levels of soluble Tau and an intraneuronal Tauexpression restricted to the locus coeruleus.22–26. The gene discussed is MAPT; the disease is Cognitive impairment.