Photon radiation is known to induce an “in situ autovaccination” effect, a means of immunoactivation in which various small molecules are expressed on tumor cells after radiation-induced cell death; these molecules include DAMPs (damage-associated molecular patterns), calreticulin, HMGB1 (high mobility group box-1), and ATP (reviewed in Wang and Frank [16]). This evidence concerns the gene HMGB1 and neoplasm.