Su et al. have recently reported that alpinetin can reduce the activity of caspase-3 and caspase-9 in COPD rats, inhibit the occurrence of alveolar cell apoptosis, and reduce the release of inflammatory factors by reducing the activities of TGF-β1, TNF-α, and α-SMA [23]. This evidence concerns the gene ACTA1 and chronic obstructive pulmonary disease.