Cancer cells are known by their ability to escape cancer drugs by hijacking autophagy; in the light of recent studies, it is idealized that blocking autophagy can help in increasing apoptosis through transcriptional factor FOXO3a which links the two processes, by maintaining autophagy equilibrium and controlling a gene responsible for making an apoptosis-facilitating protein called p53 upregulated modulator of apoptosis [71]. The gene discussed is TP53; the disease is cancer.