BRAF and adenoma: The National Cancer Institute's (NCI's) Physician's Data Query (PDQ) cancer information summary about CRC states that the majority of colon cancers today arise from an AP through the adenoma to carcinoma sequence, although serrated-type hyperplastic polyps can also transform into CRC via a BRAF (B-Raf proto-oncogene serine/threonine kinase) mutation [9].