Although Ang 1-7, the product of ACE2, does not affect intracellular pH [25], GLP-1R agonists, ACEIs, and ARBs can reduce the progression and damage of COVID-19 by causing a vasodilator and antioxidant effect through activation of the ACE2/Ang 1-7/Mas receptor pathway [2]. The gene discussed is GLP1R; the disease is COVID-19.