For example, tuina can inhibit the expression of TNF-α, IL-1, and IL-1β in the serum of patients with lumbar disc herniation [47], downregulate 5-HT and PG in the serum of patients with sciatica [48], decrease the expression of proinflammatory factor IL-6 in serum and spinal cord of CCI model, and increase the expression of anti-inflammatory protective factor SOCS3 [38]. This evidence concerns the gene IL1B and Sciatica.