GSK3B and cardiac hypertrophy: Meanwhile, GSK3B, a direct substrate of the PI3K-Akt signaling pathway, will be activated by a number of ways, including phosphorylation of GATA4, which regulates cardiac hypertrophy, phosphorylation of eIF2B to inhibit protein synthesis, and phosphorylation of glycogen synthase to inhibit glycogen synthesis to prevent cardiac hypertrophy and inhibit the progression of ventricular remodeling [12–14].