Underhill et al. (93) recently described a serum panel comprising two proteoglycans, i.e. biglycan and decorin, together with serum protein sex hormone-binding globulin (SHBG) as a promising second-trimester prenatal serum screening-based biochemical model with an ability to predict pPROM in asymptomatic women. Here, DCN is linked to preterm premature rupture of the membranes.