Phosphorylated PHB2 translocates to nuclear ERα and plasma membrane-type ERα in an E2-dependent manner, resulting in multiple suppression of E2-dependent transcriptional activity and membrane-type ERα-mediated nongenomic signaling (various phosphorylation cascades) in ERα-positive breast cancer [89, 95, 96]. Here, ESR1 is linked to breast carcinoma.