CLOCK and obesity disorder: In recent years, researchers have also proved that SIRT1 gene regulates obesity and lipid metabolism, for example, Thaddeus et al.55 pointed out that SIRT1 gene may affect obesity by regulating fatty acid oxidation in the liver, influencing obesity-induced inflammation in macrophages, sensing nutrient availability in the hypothalamus, as well as modulating the activity of the circadian clock in metabolic tissues.