CASP8 and gastric neoplasm: Among these, 2 genes were affected by high-confidence LoF germline variants: FANCG (germline splice site variant, c.307 + 1G > C) in gastric tumor of dou_004 and CASP8 (germline deletion variant, c.658_659del) in colorectal tumor of dou_010 (Table 3).