Among them, TNFα, IL-1α, IL-1 β are known to intervene in the development of an acute inflammatory response and therefore associated with the early development of SIRS, while chemokines MIP-1β and IL-8 are produced in an intermediate phase of septic shock and associated with the migration of cells from the immune system to sites of infection to promote inflammation. This evidence concerns the gene CXCL8 and systemic inflammatory response syndrome.