PTX3 and infection: PTX3 genetic variants [PTX3 (+ 1449 A > G), second intron: rs1840680, PTX3 (+ 734A > C), second exon: rs3816527, and PTX3 (C > A) 5’-UTR: rs2120243] have been associated with several clinical conditions, such as infections, female fertility, risk and progression of oral cancer29, type II diabetes nephropathy27, hypertension30 and migraine31.