Meanwhile, several studies have indicated that HIF-1α plays a role in the development of psoriasis: HIF-1α induces the expression of vascular endothelial growth factor (VEGF), which is also upregulated in psoriatic lesions, and the activation of VEGF induces psoriasis like lesions, possibly through induction of angiogenesis29,30. Here, HIF1A is linked to psoriasis.