Our results suggest that, treatment of kidney and lung carcinoma cells with garlic SEVs led to a significant increase in gene expression levels of pro-apoptotic genes such as p53, Bax, Cas3 and Cas9 while a statistically significant decrease in anti-apoptotic gene expression levels of Bcl-2 was detected in each cancer cell lines. This evidence concerns the gene TP53 and lung carcinoma.