The regions of deletion included several loci, including those coding for LRP1B (LDL receptor-related protein 1B) on 2q22.1-q22.2 and NFE2L2 (nuclear factor, erythroid 2 like 2) on 2q31.2, both of which have been implicated in ESCC carcinogenesis61,62. This evidence concerns the gene NFE2L2 and esophageal squamous cell carcinoma.