The TCGA Pan-Cancer cohort showed six genes [METTL1, METTL11B, EEF1AKNMT, METTL18, EEF1AKMT3 (METTL21B), RRNAD1 (METTL25B)] with high-level amplifications above 2% (Fig. 1B, Supplementary Table S3). The gene discussed is METTL25B; the disease is cancer.