In contrast, three METTLs (METTL7A, METTL24, ETFBKMT) were under-expressed (log2 FC <  − 1, FDR < 0.05) in at least three of 15 TCGA tumor types compared to normal samples (Fig. 2A, Supplementary Tables S6, S7). This evidence concerns the gene TMT1A and neoplasm.